Volume 3, Issue 1, January 2017, Page: 1-4
Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya
Ashraf Ahmed Ahmed, Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Al-Neelain, Khartoum, Sudan
Siddig Bushra Mohamed, Department of Medical Laboratory Sciences, Faculty of Medical Technology, Sabratha University, Surman, Libya
Salih Abdelgadir Elmadi, Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, The National Ribat University, Khartoum, Sudan
Abdelkarim A. Abdorabo, Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Al-Neelain, Khartoum, Sudan
Ismail Mohamed Ismail, Department of Biochemistry and Molecular Biology, Faculty of Sciences and Technology, University of Al-Neelain, Khartoum, Sudan
Amar Mohamed Ismail, Department of Biochemistry and Molecular Biology, Faculty of Sciences and Technology, University of Al-Neelain, Khartoum, Sudan
Received: Feb. 19, 2017;       Accepted: Mar. 1, 2017;       Published: Apr. 18, 2017
DOI: 10.11648/j.ijcems.20170301.11      View  2284      Downloads  88
Abstract
Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The study aim to find out the prevalence of thyroid disorders in type 2 diabetes mellitus patients. In a cross-sectional study 369 diagnosed type 2 DM patients, of which 203 are males and 166 are females, age reneged from (18 to 73) were enrolled, from July 2016 to July 2016. Their demographic data were obtained by through a questionnaire. Serum FT3, FT4, TSH and thyroid Antibodies (Tg-Ab, AM-Ab and TR-Ab) were measured using TOSOH, ELISA and enzymatic methods respectively. Out the 369 type 2 DM patients, of whom 9.5% are thyroid disorders, 2.3% have hypothyroidism, 5.0% subclinical hypothyroidism and 2.2% hyperthyroidism. Thyroid disorders are more common in female’s 16.5:1 fold. Compared with the control group, hypothyroid and subclinical hypothyroid DM patients have significant increase in TSH while significant decreases were observed in FT3 and FT4. TSH was significantly lower while FT3 and FT4 were significantly higher in hyperthyroidism DM patients. Moreover 23.3% of hypothyroidism has positive Tg-Ab, 23.3% has AM-Ab and 100% of hyperthyroidism has positive TR-Ab. The data suggested that, the prevalence of thyroid diseases is common in type 2 DM Libyan patients. Autoantibodies are the main causes of thyroid dysfunction, therefore, could predict and increase risk of thyroid disease, especially in females.
Keywords
Type 2 Diabetes Mellitus, Thyroid Dysfunction, Autoantibodies, Libya
To cite this article
Ashraf Ahmed Ahmed, Siddig Bushra Mohamed, Salih Abdelgadir Elmadi, Abdelkarim A. Abdorabo, Ismail Mohamed Ismail, Amar Mohamed Ismail, Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya, International Journal of Clinical and Experimental Medical Sciences. Vol. 3, No. 1, 2017, pp. 1-4. doi: 10.11648/j.ijcems.20170301.11
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Rubina Mansoor, Syed Shakeel Raza Rizvi, Waseem Kausar, Faiza Aslam, Sibga Tul Huda, Comparison of TSH, T4 and T3 Levels in Primary Hypothyroidism in relation to gender and age in a Tertiary Care Hospital Ann. Innovative Journal of Medical and Health Science, 2011; 7 (4): 186-190.
[2]
Makandar Asmabi, Sonagra Amit D, Biradar Shivaleela M, Quadri Shireen Swaliha, Effect of Thyroid Dysfunction on Metabolic Response in Type 2 Diabetic Patients. Unique Journal of Medical and Dental Sciences, 2015; 03 (01): 65-69.
[3]
Ramesh V, Geetha R, Anitha D, Nrvk S, Thangarajan T. P. The Study of Thyroid Dysfunction among Type 2 Diabetic Patients, international Journal of Current Research and Academic Review, 2015; 3 (9): 14-18.
[4]
Kiran Nagaraju, Amin Pirouz, Tayebeh Sadeghi, Pegah Esmaeili. Prevalence of thyroid dysfunction and its management in diabetic patients attending out patients clinic of Kim Hospital. International research journal of pharmacy, 2013, 4 (9): 132-35.
[5]
Ray KK, Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Preiss D, Erqou S, Sattar N. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a metaanalysis of randomised controlled trials. The Lancet-Journal - Elsevier, 2009; 373 (9677): 1765-1772.
[6]
Udoing CEJA, Udoh E, Etukudoh ME. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Indian Journal Clinical of Biochemistry, 2007; 22 (2): 74-78.
[7]
Singh G, GuptaV, Sharma AK, Gupta N. Evaluation of Thyroid Dysfunction Among type 2 diabetic Punjabi population. Advances Bioresearch journal 2011; 2 (2): 3-9.
[8]
Padma V. and Anand N N. Prevalence of Thyroid Dysfunction in Type 2 Diabetic Patients. International Journal of Pharmacy Biochemistry Sciences, 2015; 6 (3): 289-294.
[9]
Sudha J, Naved A, Prevalence of Thyroid Dysfunction in the Patients Visiting Tertiary Health Care Hospital, Faridabad; Haryana, International Journal of Scientific Research, 2013; 2 (10): 2277-8179.
[10]
Akbar DH, Ahmed MM, Al-Mughales J. Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics. Acta Diabetol journal, 2006; 43 (1): 14-18.
[11]
Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. International Journal of Clinical Practice 2010; 64 (8): 1130-1139.
[12]
Kapadia K, Bhatt P, and Shah J. Association between altered thyroid state and insulin resistance. Journal of Pharmacology & Pharmacotherapeutics, 2012; 3 (2): 156-160.
[13]
Yang, G. R., Yang, J. K., Zhang, L., An, Y. H., Lu, J. K. 2010. Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case control study. Tohoku Journal Experimental Medicine, 222 (4): 303-310.
[14]
Athanasia P. B, Alexios S, Anthi K, Marina K, Petroula S, Stavros P, Prevalence of Thyroid Dysfunction Among Greek Type 2 Diabetic Patients Attending an Outpatient Clinic, Journal of Clinical Medical Research, 2010; 2 (2): 75-78.
[15]
Akbar DH, Ahmed M. M, Al-Mughales J, Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics. Acta Diabetologica, Acta Diabetol journal, 2006; 43 (1): 14-18.
[16]
Ana Paula Santin and Tania weber Furlametto. Role of Estrogen in Thyroid Function and Growth regulation. Journal of Thyroid Research, 2011; 1-7.
[17]
Chaoxun Wang. The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases, J Diabetes Res. 2013; 1-8.
[18]
Naveet Agrawwal, Manoj Gulati, Study of prevalence of thyroid dysfunction in patients with type 2 diabetes mellitus. International Journal of Contemporary medical research, 2016; 3 (8): 2212-2214.
[19]
Manjunath SC, Krishnamurthy V, Puttaswamy BK. Prabhu S, Vishwanathaiah PM. Prevalence of subclinical thyroid disorders in type 2 diabetes mellitus. International Journal of Medical Public Health, 2013; 3: 330-334.
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