Volume 4, Issue 2, March 2018, Page: 21-25
Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model
Masanori Watanabe, Department of Physical Therapy, Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan
Satoshi Kojima, Course of Rehabilitation, Graduate School of Rehabilitation, Kinjo University, Hakusan, Japan
Keiji Asada, Department of Physiotherapy, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Japan
Itaru Hibino, Department of Physical Therapy, Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan
Masahiro Hoso, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
Received: Mar. 28, 2018;       Accepted: Apr. 17, 2018;       Published: May 10, 2018
DOI: 10.11648/j.ijcems.20180402.11      View  1378      Downloads  76
Abstract
This study aimed to investigate and clarify the effect of aging on the progression of cartilage damage using a rat osteoarthritis model. In total, 12 rats, including three rats per age group, were assigned to the experimental group, and two rats (one 3 and 18 months old each) were assigned to the control group. In the experimental group, joint instability was induced using the destabilization of the medial meniscus model. After completion of the 4-week experimental period, the bilateral knee joints were harvested and the histological changes in the articular structures of the joints were observed using a light microscope. Medial dislocation of the medial meniscus, low staining of the cartilaginous substrate on the tibial side localized around the medial meniscus tip, and irregularities and fibrillation of the superficial layer of the cartilage on the tibial side were observed in all experimental age groups. No significant age-related differences were observed in the degree of observed findings and the score of cartilage degeneration. The results indicate that aging does not affect the early stages of progression of cartilage damage.
Keywords
Osteoarthritis, Aging, Histopathology
To cite this article
Masanori Watanabe, Satoshi Kojima, Keiji Asada, Itaru Hibino, Masahiro Hoso, Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model, International Journal of Clinical and Experimental Medical Sciences. Vol. 4, No. 2, 2018, pp. 21-25. doi: 10.11648/j.ijcems.20180402.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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