Volume 4, Issue 3, May 2018, Page: 46-50
The Role of Gap Junction in Regulating Vascular Function and Its Relationship with Hypertension
Jian Hu, Department of Geriatrics, the People's Hospital of Jiangxi Province, Nanchang, China
Shiying Liu, Department of Geriatrics, the People's Hospital of Jiangxi Province, Nanchang, China
Yuanzhi Qiu, Department of Geriatrics, the People's Hospital of Jiangxi Province, Nanchang, China
Received: Jun. 11, 2018;       Accepted: Jul. 30, 2018;       Published: Aug. 27, 2018
DOI: 10.11648/j.ijcems.20180403.14      View  555      Downloads  29
Abstract
Gap junction (GJ), also called as gap connection, communication connection, is a special membrane structure which consisted of connecting channels in two adjacent cells. Intercellular communication can be divided into indirect and direct communication. Direct communication is a cell-to-cell communication mediated by GJ between adjacent cells. Direct communication is also called as gap junction intercellular communication (GJIC). Adjacent cells exchange information, energy, and substances by using direct communication. They participate in the metabolic coupling of cell-to-cell substances exchanges and the electrical coupling of electrical signals. They play important roles in regulating physiological processes including metabolism, homeostasis, proliferation, and vasodilation of vascular smooth muscle so on. This article will focus on introducing the progresses of studies on the morphology, structure and function of GJ in details. Blood pressure is the force exerted by the blood against the walls of the blood vessels. A blood pressure higher than 130 over 80 millimeters of mercury (mmHg) is defined as hypertension. Hypertension and heart disease are global diseases. Hypertension was correlated with many factors, which contributed to hypertension by many mechanisms including sodium, potassium, Gap junction and so on. The studies on GJ and hypertension were also introduced in details, such as hypertension and expression of Cx, Ca2+ and GJ, Genetic Polymorphism of Cx40 and Hypertension.
Keywords
Gap Junctions, Connexins, Cardiovascular System, Hypertension
To cite this article
Jian Hu, Shiying Liu, Yuanzhi Qiu, The Role of Gap Junction in Regulating Vascular Function and Its Relationship with Hypertension, International Journal of Clinical and Experimental Medical Sciences. Vol. 4, No. 3, 2018, pp. 46-50. doi: 10.11648/j.ijcems.20180403.14
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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