Research Article
Lipid Profile and Blood Sugar Variations Among Hypertensive Subjects in Yenagoa, Nigeria
Issue:
Volume 11, Issue 1, February 2025
Pages:
1-10
Received:
6 March 2025
Accepted:
18 March 2025
Published:
31 March 2025
Abstract: Hypertension is the leading risk factor for death and disability worldwide and a major contributor to premature mortality. Individuals with hypertension often exhibit alterations in lipid and glucose metabolism, further increasing their risk of severe cardiovascular complications. The present study evaluated the lipid profile and blood sugar among hypertensive individuals in Yenagoa, Nigeria. A total of 246 subjects (31-60 years) were recruited for the study. They consisted of 172 hypertensives attending the Cardiology Clinic of Niger Delta University Teaching Hospital (NDUTH) and 74 normotensive control subjects drawn from the staff of NDUTH. Body mass index, fasting blood sugar and lipid profile were measured following standard protocols. The result of this study shows a significantly elevated mean levels of fasting blood sugar (FBS), total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) among hypertensive subjects compared to the normotensive controls (p<0.05). Fasting blood sugar showed sex and age-dependent variations among the hypertensives. Male hypertensive subjects had a significantly higher fasting blood sugar compared to the female hypertensives (p<0.05). Also, fasting blood sugar increased with age for both hypertensive and normotensive subjects regardless of gender. The current evidence has identified elevated BMI, FBS, TC, TG, and LDL among hypertensive patients receiving medical care at a tertiary healthcare facility in Yenagoa, Nigeria. These findings underscore the significant association between hypertension and metabolic risk factors and recommend routine assessments of these metabolic parameters among hypertensive patients.
Abstract: Hypertension is the leading risk factor for death and disability worldwide and a major contributor to premature mortality. Individuals with hypertension often exhibit alterations in lipid and glucose metabolism, further increasing their risk of severe cardiovascular complications. The present study evaluated the lipid profile and blood sugar among ...
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Research Article
Impact of Intermittent Fasting on Serum Cardiac Biomarkers in Male Wistar Rats
Issue:
Volume 11, Issue 1, February 2025
Pages:
11-17
Received:
19 March 2025
Accepted:
31 March 2025
Published:
22 April 2025
Abstract: Background: Intermittent fasting (IF) is a widely adopted strategy for weight loss; however, it has also been linked to potential risks, including an increased likelihood of cardiovascular complications. This study aimed to investigate the effects of intermittent fasting on cardiac biomarkers in male Wistar rat models. Methods: Twenty (20) male Wistar rats (130 g) were used for the study. They were randomly assigned to four (4), consisting of five (5) rats per group. Group I served as the control while groups II, III, and IV served as the experimental groups and intermittently fasted for 6 hours, 8 hours, and 12 hours, respectively, for four (4) weeks. Blood samples were collected to determine cardiac serum biomarkers: troponin-I (cTnI), troponin-T (cTnT), and aspartate transaminase (AST). Results: There was a significant increase in cTnI, cTnT, and AST levels among the 12-hour intermittent fasting group (IV) compared to the control group (I), the 6-hour IF (II) and the 8-hour IF (III) groups (p<0.05). Similarly, mean levels of cTnI, cTnT, and AST were significantly elevated among the 8-hour IF group compared to the 6-hour IF group (p<0.05). Expectedly, there was a reduction in the body weight of the rats in all experimental groups compared to the control (p<0.01). Conclusion: Prolonged intermittent fasting could pose a risk to cardiac health, necessitating careful consideration and monitoring of the fasting regime.
Abstract: Background: Intermittent fasting (IF) is a widely adopted strategy for weight loss; however, it has also been linked to potential risks, including an increased likelihood of cardiovascular complications. This study aimed to investigate the effects of intermittent fasting on cardiac biomarkers in male Wistar rat models. Methods: Twenty (20) male Wis...
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Wadioni Aduema
